Hepatic and renal functions, and tissue biopsy were measured in rats with therapeutic, toxic and lethiferous dose treatment after a period of time. 分别测定治疗剂量、中毒剂量、致死剂量组小鼠在用药一段时间后的肝肾功能,并进行组织病理学检查。
Experimental Study of Subacute Toxic Effects of Herba Leonuri at High Dose in Rats 大剂量益母草对大鼠肝、肾的亚急性毒性作用
Correlations of Phenytoin Concentrations among Saliva and Plasma or Tissues after iv Administration of Toxic Dose of Phenytoin to Rats 大鼠静注中毒剂量苯妥英钠后唾液与血浆及组织中药物浓度相关性研究
Aim: To obtain the original toxic materials and evaluate the toxic grade and decide clinical safe dose, we observed the response and extension of the acute toxicity that the big dose Onychin induced the mouse. 目的观察金粉蕨素(Onychin)的毒性,为评价其毒性等级以及拟定临床安全剂量提供依据。
Methods After administered with cholinesterase inhibitor omethoate at the toxic dose of 30mg · kg-1 po ( 1.2LD), all the mice were dead. 方法胆碱酯酶抑制剂氧化乐果在30mg·kg-1po中毒剂量(1.2个致死剂量,1.2LD)下,可诱发全部的受试昆明种小鼠死亡。
Cellular Toxic Effect of Low Dose Cisplatin Combined with Interstitial Injection of~ ( 32) P Glass Microspheres on Mouse Solid Tumor S180 小剂量顺铂联合~(32)P玻璃微球对小鼠S180瘤细胞的细胞毒作用
Objective To observe the chronic toxic effect of CXL in the rat with large dose and long term administration. 目的观察消抗安胎口服液(CXL)长期、大剂量使用对大鼠的慢性毒性作用。
[ Conclusion] It was safe to use fluoride foam when fluorid foam concentration was lower than total dose in need and chronic toxic dose. 【结论】使用氟化泡沫后,氟的摄入量小于每日总氟适宜摄入量及每日慢性中毒量,氟化泡沫使用是安全的。
It is toxic and dose serious harmer to environment. 残留期长,对环境有严重危害。
The biological effect and physiological function, requirements, tolerance, toxic dose of copper in dairy cattle were reviewed. 本文就铜的生物学效应和生理功能,奶牛对铜的需要量、耐受量和中毒量等进行阐述。
The toxic symptoms of plant showed an evident correlation between dose and effect; 植物受毒害的程度表现出明显的剂量效应关系;
As the therapeutic dose and the toxic dose of theoclears were quite similar, the clinical use of which should be restricted to some extent, yet the prospect on the study of their extensive pharmacological actions is potential. 茶碱类药物治疗剂量和中毒剂量较接近,临床应用受到一定限制,但其药理作用广泛仍有潜在的研究前景。
Chronopharmacokinetics of aminophylline at a toxic dose in rats 大鼠体内中毒剂量氨茶碱的时辰药物动力学
The toxic test suggested that the maximal tolerance dose of mice with its extract a day was 220 times as much as clinical administration dose. 毒性试验表明,小鼠一天口服王老吉浸膏最大耐量为临床口服量的220倍。
The ratio between toxic and effective dose was less than 2. 中毒量与有效量之比低于2。
Ca~ ( 2+) oscillation of cerebral cortical neurons induced by glutamate of toxic dose and its mechanism 中毒剂量谷氨酸引起大脑皮质神经细胞的钙振荡及其机制探讨
The toxic effects were reversible and were dose dependent. 中毒反应是可恢复的,反应程度与用药剂量有关。
Conclusion: The metabolism of Aristolochia Fangchi extract in a toxic dose was correspondence to two-compartment model, and the distribution of AA-I and AL-I was wide and the accumulation of them was specific. 结论:毒性剂量下的广防己提取物在大鼠体内的代谢符合血管外给药二室开放模型,AA-I及AL-I的组织分布较广泛,其蓄积具有特异性。
Toxic Reaction of Middle Dose Ara-C ( MD-Ara-C) in Child Leukemia and the Treatment 儿童白血病应用中剂量阿糖胞苷的毒副作用及处理
Result Mice had no acute toxic reaction in maximum tolerable dose. 结果小鼠按照最大耐受量灌胃,未见急性毒性反应;
The results showed that gentamycin has harm to kidney in therapeutic dose and more serious harm was found in toxic dose. 结果表明,治疗剂量庆大霉素对肾脏具有损伤作用,中毒剂量损伤明显加重。
Study on Urea Toxic Dose in Rabbit 兔尿素的中毒剂量
( 1) The results of acute toxicity experiments in mouses: there were not any poisoned symptom and death of mouse during 14 day-long observation periods. the samples accord to the actual non-toxic level according to the acute toxic dose graduation standard. 经小鼠急性毒性实验:在14天的观察期内未见动物有任何中毒表现,无一动物死亡,按急性毒性剂量分级标准属实际无毒级物质。
Objective: In recent years, paraquat poisoning reports are presenting an increasing trend, which owns the feature of toxic dose small, nor-effective antidote, nor-effective therapy, which leads to the increased mortality of PQP. 目的:近来百草枯中毒的报道呈逐年增加的趋势,中毒剂量小,无特效解毒药,又无确切有效的治疗措施,致使百草枯中毒死亡率高。
Se has extremely narrow window between its beneficial and toxic dose, in fact, it is toxic at the level not much higher than the beneficial requirement. 硒的特点是有益剂量和毒性剂量之间范围狭窄,高于有益需求的水平就具有毒性。
They were randomly divided into the HP+ HD group and HP+ HF group, and there was no obvious difference in the aspects of age, toxic dose, toxicant time and initial concentration of paraquat. 随机分为HP+HD组和HP+HF组,两组在年龄、服毒量、中毒至入院时间、百草枯初始血药浓度方面经统计学分析无明显差异。
The results suggest that SEBS was safe with no acute and genetic toxic effect in the tested dose range. 结果显示在本实验使用的剂量范围内富硒大麦苗无急性毒性和遗传毒性,是安全可靠的。